There are two international aiports in Tuscany; Galileo Galilei International Airport
in Pisa and Amerigo Vespucci (Peretola) Airport
, in Florence. The distance between these airports is only 80km.
The Pisa airport is the larger of the two and handles flights to major European cities.
Direct flights from North America are generally more expensive than stopover routes somewhere else in Europe. More affordable fares can be had if one flies non-stop to a major European city such as London or Paris and then takes a Ryan Air (low-fare European airline) flight direct to Pisa. You'll have to change airports in London and Paris, though, as Ryan Air generally uses secondary airports.
The Pisa airport has direct access to both the Firenze-Pisa-Livorno dual carriageway (Pisa Centro - Aeroporto exit), to the Genova-Rosignano A12 motorway (Pisa Centro exit), to the Firenze-Pisa A11 (through the Pisa Nord linking stretch with the A12) and to road SS1 "Aurelia". The terminal is also directly connected to Pisa Central Station by direct train service, with many trains to the Pisa central station and with eight trains a day from the Pisa airport to the main Florence train station. The railway terminal is located just outside the departures hall. You can also reach the center of Pisa with bus or taxi service.
The Florence airport also has direct access to the Firenze-Pisa A11 motorway as well as to the A1 "Autostrada del Sole". The airport is located on the north western edge of Florence; taxis and a bus shuttle connect the airport to Florence's historical center.